Virosart HF
Virosart® HF combines the highest level of virus safety with flexible capacities for virus-retentive filtration of monoclonal antibodies, antibody fragments, or small recombinant proteins. The filter provides all the coverage required to improve your process quality by targeting both non-enveloped viruses such as MVM and vesivirus, as well as large enveloped viruses such as MuLV.
Virosart® HF ready-to-use virus filter is compact and powerful, reducing footprint by 90%. The single-use design is gamma compatible and easy to implement in mAb processes, helping to reduce costly sanitization and flushing volumes by 80%.
Product Code: 3VI--28-MC-SF
Virosart® HF combines the highest virus safety with superior capacities for mAbs and recombinant proteins. The filter is specifically designed for easy implementation in single-use processes with its smart capsule design, low footprint, and minimal flushing volumes.
Target Molecule
The primary application of Virosart® HF for virus-retentive filtration is monoclonal antibodies (mAbs), antibody fragments (Fab), or small recombinant proteins (< 150 kD).
Positioning
Virosart® HF is used toward the end of the purification process for viral filtration of the biopharmaceutical product.
Working Principle
Virus filtration operates based on size exclusion. Small non-enveloped and large enveloped viruses are retained by the 20 nm asymmetric membrane structure.
Virus Risk Reduction
State-of-the-art, robust virus clearance performance
≥ 4 LRV for small non-enveloped viruses
≥ 6 LRV for large enveloped viruses
Cost Efficiency
Threefold capacity increase at high flow rates and reduced flushing buffer volume provide a cost-effective solution
The capsule design avoids costly investments in stainless steel filtration systems and accessories
High filter packing density reduces cleanroom footprint
Handling
Includes a suitable water-based integrity test to ensure reliability
Sterile shipping options help advance the reduction of bioburden risk.
