HEA HyperCel
HEA HyperCel is a mixed-mode ligand featuring a less hydrophobic hexylamine chain that enables protein binding at neutral pH under moderate salt concentrations.
Product Code: SR6HEA
HEA HyperCel resin is an industrially scalable chromatography resin designed for protein capture and impurity removal in biopharmaceutical environments.
Its behavior is based on a mixed-mode mechanism utilizing a hexylamine ligand, where protein binding results from a combination of electrostatic and hydrophobic interactions between proteins and the ligand. HEA HyperCel resin provides unique selectivities that differ from those achieved with ion exchange chromatography or traditional Hydrophobic Interaction Chromatography (HIC).
Features and Benefits
- High mechanical and chemical stability
- Suitable for large-scale chromatography in biopharmaceutical manufacturing
- Cross-linked cellulose-based matrix
Applications
- Protein purification at low ionic strength through direct hydrophobic capture
- Separation of challenging mixtures, such as protein isoforms or proteins with very similar isoelectric points
- Orthogonal separation mechanism relative to ion exchange chromatography or HIC
